| Tartalom: |
http://dx.doi.org/10.1371/journal.pbio.0040036 |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
Autophagy: A Forty-Year Search for a Missing Membrane Source
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| Létrehozó: |
Juhász, Gábor
Neufeld, Thomas P.
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| Kiadó: |
Public Library of Science
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| Dátum: |
2006
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| Téma: |
QH3011 Biochemistry / biokémia
QH3015 Molecular biology / molekuláris biológia
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| Tartalmi leírás: |
Autophagy is the major self-degradative process in eukaryotic cells, with fundamental roles in cellular and organismal homeostasis, and is involved in many developmental and pathological situations. Structures
targeted for autophagic destruction are sequestered into newly emerging double-membrane vesicles called autophagosomes, and delivered for lysosomal degradation.
Despite recent advances in understanding the molecular
mechanisms of autophagy, a long-standing question concerning the source of the autophagic membrane remains unresolved. Two major alternatives can be considered: the membrane may be derived from a pre-existing cytoplasmic organelle such as the endoplasmic reticulum (maturation model), or assembled from constituents at its site of genesis (assembly model).
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| Típus: |
Article
PeerReviewed
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| Formátum: |
application/pdf
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| Azonosító: |
Juhász, Gábor and Neufeld, Thomas P. (2006) Autophagy: A Forty-Year Search for a Missing Membrane Source. PLoS Biology, 4 (2). e36. ISSN 1544-9173 (print), 1545-7885 (online)
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| Kapcsolat: |
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