Fermented Wheat Germ Extract Reduces Chemotherapy-Induced Febrile Neutropenia in Pediatric Cancer Patients
  • Metaadatok
Tartalom: http://dx.doi.org/10.1097/01.mph.0000141897.04996.21
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published



Type = Article
Cím:
Fermented Wheat Germ Extract Reduces Chemotherapy-Induced Febrile Neutropenia in Pediatric Cancer Patients
Létrehozó:
Garami, Miklós
Schuler, Dezső
Babosa, Mária
Borgulya, Gábor
Hauser, Péter
Müller, Judit
Paksy, András
Szabó, Enikő
Hidvégi, Máté
Fekete, György
Kiadó:
Lippincott, Williams and Wilkins
Dátum:
2004
Téma:
RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
RJ Pediatrics / gyermekgyógyászat
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
Purpose: An open-label, matched-pair (by diagnosis, stage of disease, age, and gender) pilot clinical trial was conducted to test whether the combined administration of the medical nutriment MSC (Avemar) with cytotoxic drugs and the continued administration of MSC on its own help to reduce the incidence of treatment-related febrile neutropenia in children with solid cancers compared with the same treatments without MSC.
Methods: Between December 1998 and May 2002, 22 patients (11 pairs) were enrolled in this study. At baseline, the staging of the tumors was the same in each pair (mostly pTNM T2N0M0), with the exception of two cases in which patients in the MSC group had worse prognoses (metastasis at baseline). There were no significant differences in the average age of the patients, the length of treatment time (MSC) or follow-up, the number of patients with central venous catheters, the number of chemotherapy cycles, the frequency of preventive counterneutropenic interventions, or the type and dosage of antibiotic and antipyretic therapy used in the two groups.
Results: During the treatment (follow-up) period.. there was no progression of the malignant disease, whereas at end-point the number and frequency of febrile neutropenic events significantly differed between the two groups: 30 febrile neutropenic episodes (24.8%) in the MSC group versus 46 (43.4%) in the control group (Wilcoxon signed rank test, P < 0.05).
Conclusions: The continuous supplementation of anticancer therapies with the medical nutriment MSC helps to reduce the incidence of treatment-related febrile neutropenia in children with solid cancers.
Típus:
Article
PeerReviewed
Formátum:
application/pdf
Azonosító:
Garami, Miklós and Schuler, Dezső and Babosa, Mária and Borgulya, Gábor and Hauser, Péter and Müller, Judit and Paksy, András and Szabó, Enikő and Hidvégi, Máté and Fekete, György (2004) Fermented Wheat Germ Extract Reduces Chemotherapy-Induced Febrile Neutropenia in Pediatric Cancer Patients. Journal of Pediatric Hematology/Oncology, 26 (10). pp. 631-635. ISSN 1077-4114 (print), 1536-3678 (online)
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