| Tartalom: |
http://dx.doi.org/10.1016/j.canlet.2005.05.037 |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine
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| Létrehozó: |
Kemény-Beke, Ádám
Aradi, János
Damjanovich, Judit
Beck, Zoltán
Facskó, Andrea
Berta, András
Bodnár, Andrea
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| Kiadó: |
Elsevier
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| Dátum: |
2006
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| Téma: |
RE Ophthalmology / szemészet
RZ Other systems of medicine / orvostudomány egyéb területei
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| Tartalmi leírás: |
The benzophenanthridine alkaloids sanguinarine, chelerythrine and chelidonine were reported previously to provoke cell death in a variety of tumor cells suggesting their potential application as anticancer agents. Here we tested their effects on a primary human uveal melanoma cell line, OCM-1. Flow cytometric analysis of annexin V binding/PI exclusion and DNA fragmentation disclosed that all these alkaloids could induce apoptosis in OCM-1 cells. Moreover, necrotic cell death was also observed upon alkaloid treatment. As it was also evidenced by light microscopic inspection of cellular morphology, chelidonine primarily caused apoptosis, while sanguinarine and chelerythrine were effective via a so-termed bimodal cell death (apoptosis and primary necrosis). The relative efficiencies of the two modes depended on the applied dose. This study is the first implication for the possible use of these alkaloids in the therapy of uveal melanomas, for which no really efficient therapeutic regimen is available so far.
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| Típus: |
Article
PeerReviewed
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| Formátum: |
application/pdf
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| Azonosító: |
Kemény-Beke, Ádám and Aradi, János and Damjanovich, Judit and Beck, Zoltán and Facskó, Andrea and Berta, András and Bodnár, Andrea (2006) Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. Cancer Letters, 237 (1). pp. 67-75. ISSN 0304-3835
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