| Tartalom: |
http://dx.doi.org/10.1016/S0304-3940(03)00191-5 |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
Perineural capsaicin treatment attenuates reactive hyperaemia in the rat skin
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| Létrehozó: |
Domoki, Ferenc
Sántha, Péter
Bari, Ferenc
Jancsó, Gábor
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| Kiadó: |
Elsevier
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| Dátum: |
2003
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| Téma: |
QH301 Biology / biológia
QP Physiology / élettan
RZ Other systems of medicine / orvostudomány egyéb területei
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| Tartalmi leírás: |
The neural mechanisms of reactive cutaneous hyperaemia were studied by using a novel experimental approach: the simultaneous measurement of cutaneous blood flow by laser-Doppler flowmetry in adjacent innervated and chemodenervated skin regions of the rat hindpaw served by the same artery. Transient occlusion of the femoral artery (0.5-6 min) resulted in reactive hyperaemia that was greatly reduced in the chemodenervated region. After 3 min arterial occlusion, peak cutaneous blood flow was 109 +/- 13% vs. 53 +/- 7%* (% change from baseline, n = 11, *P < 0.05), and the total hyperaemic response was 110 +/- 21 vs. 52 +/- 12* (arbitrary perfusion units) in intact vs. chemodenervated skin regions, respectively. The findings provide clear evidence for the involvement of peptidergic capsaicin-sensitive afferent nerves in the mechanism of reactive cutaneous hyperaemia.
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| Típus: |
Article
PeerReviewed
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| Formátum: |
application/pdf
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| Azonosító: |
Domoki, Ferenc and Sántha, Péter and Bari, Ferenc and Jancsó, Gábor (2003) Perineural capsaicin treatment attenuates reactive hyperaemia in the rat skin. Neuroscience Letters, 341 (2). pp. 127-130. ISSN 0304-3940
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