Use of a recombinant pseudorabies virus to analyze motor cortical reorganization after unilateral facial denervation
  • Metaadatok
Tartalom: http://cercor.oxfordjournals.org/content/15/4/378
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Use of a recombinant pseudorabies virus to analyze motor cortical reorganization after unilateral facial denervation
Létrehozó:
Horváth, Szatmár
Prandovszky, Emese
Pankotai, Eszter
Kis, Zsolt
Farkas, Tamás
Boldogkői, Zsolt
Boda, Krisztina
Janka, Zoltán
Toldi, József
Kiadó:
Oxford University Press (OUP)
Dátum:
2005-04
Téma:
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
A unilateral facial nerve injury (n7x) was found to influence the transcallosal spread of the attenuated strain of pseudorabies virus (PRV Bartha) from the affected (left) primary motor cortex (MI) to the contralateral MI of rats. We used Ba-DupLac, a recombinant PRV strain, for the tracing experiments since this virus was demonstrated to exhibit much more restricted transportation kinetics than that of PRV Bartha, and is therefore more suitable for studies of neuronal plasticity. Ba-Duplac injection primarily infected several neurons around the penetration channel, but hardly any transcallosally infected neurons were observed in the contraleral MI. In contrast, after right facial nerve injury, Ba-DupLac was transported from the primarily infected neurons in the left MI to the contralateral side, and resulted in the labeling of several neurons due to a transneuronal infection. These results reveal that a peripheral nerve injury induces changes in the Ba-DupLac infection pattern in the related cortical areas. These findings and the literature data suggest that this phenomenon may be related to the changes in the expression or to the redistribution of cell-adhesion molecules, which are known to facilitate the entrance and/or transmission of PRV into neurons.
Típus:
Article
PeerReviewed
Formátum:
application/pdf
Azonosító:
Horváth, Szatmár and Prandovszky, Emese and Pankotai, Eszter and Kis, Zsolt and Farkas, Tamás and Boldogkői, Zsolt and Boda, Krisztina and Janka, Zoltán and Toldi, József (2005) Use of a recombinant pseudorabies virus to analyze motor cortical reorganization after unilateral facial denervation. Cerebral Cortex, 15 (4). pp. 378-384. ISSN 1047-3211 (print), 1460-2199 (online)
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