Novel calretinin and reelin expressing neuronal population includes Cajal-Retzius-type cells in the neocortex of adult pigs
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Tartalom: http://www.sciencedirect.com/science/article/pii/S0306452...
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published



Type = Article
Cím:
Novel calretinin and reelin expressing neuronal population includes Cajal-Retzius-type cells in the neocortex of adult pigs
Létrehozó:
Ábrahám, Hajnalka
Tóth, Z.
Bari, Ferenc
Domoki, Ferenc
Seress, László
Kiadó:
Elsevier
Dátum:
2005
Téma:
QP Physiology / élettan
R1 Medicine (General) / orvostudomány általában
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
Cajal-Retzius cells and their secreted product reelin are essential for the lamination of the cerebral cortex. In all species studied to date Cajal-Retzius cells form a transient
neuronal population that almost completely disappears from
the neocortex postnatally. Recently, in the hippocampal for-
mation of adult domestic pig, we have found a large calreti-
nin- and reelin-immunoreactive cell population that morpho-
logically corresponded to Cajal-Retzius cells. In the present study, we examined calretinin- and reelin-
immunoreactive neurons in layer I of the prefrontal, temporal, parietal and occipital neocortical areas of newborn, young adult and adult domestic pigs. Large numbers of bipolar or fusiform calretinin-positive cells were found in the upper half of layer I in all examined age groups. The morphology of these neurons resembled that of the Cajal-Retzius cells. Layer I was occupied by a dense calretinin-positive axonal plexus that was similar to the previously described axons of Cajal-Retzius cells in other species. In a similar location, where calretinin-positive cells occurred in layer I, large numbers of reelin-immunoreactive cells were found in all examined age groups. In addition, reelin colocalized with calretinin in layer I neurons. The number of calretinin and reelin-positive neurons decreased from 1 day to one year, but calretinin-positive Cajal-Retzius-type cells still comprised a remarkable large population in 12-month-old animals. Correlated light and electron microscopic examination of calretinin-labeled Cajal-Retzius-type cells indicated that these cells are integrated in the synaptic circuitry of the neocortex.
Our results suggest that Cajal-Retzius cells do not disap-
pear inevitably from the mature neocortex in all mammalian
species. The function of this cell type is not known, but late persisting Cajal-Retzius-type cells in the domestic pig provide an opportunity to study their neuronal connections and the possible role of reelin in plasticity and regeneration of neocortex.
Típus:
Article
PeerReviewed
Formátum:
application/pdf
Azonosító:
Ábrahám, Hajnalka and Tóth, Z. and Bari, Ferenc and Domoki, Ferenc and Seress, László (2005) Novel calretinin and reelin expressing neuronal population includes Cajal-Retzius-type cells in the neocortex of adult pigs. Neuroscience, 136 (1). pp. 217-230. ISSN 0306-4522
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