Chlamydia pneumoniae in atherosclerotic middle cerebral artery
  • Metaadatok
Tartalom: http://stroke.ahajournals.org/content/32/9/1973
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published



Type = Article
Cím:
Chlamydia pneumoniae in atherosclerotic middle cerebral artery
Létrehozó:
Virók, Dezső
Kis, Zoltán
Karai, László
Intzédy, László
Burián, Katalin
Szabó, Árpád
Iványi, Béla
Gönczöl, Éva
Kiadó:
American Heart Association
Dátum:
2001
Téma:
QR Microbiology / mikrobiológia
RB Pathology / patológia, kórtan
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
Background and Purpose?Atherosclerotic middle cerebral arteries are frequent sites of thrombosis, leading to stroke. Previous studies have suggested a role for Chlamydia pneumoniae in the pathogenesis of atherosclerosis. However, the presence of this pathogen in atherosclerotic middle cerebral arteries has heretofore not been documented. In the present study, we analyzed atheromatous plaques from middle cerebral arteries for the presence of C pneumoniae.
Methods?Atherosclerotic middle cerebral arteries from 15 cadavers who died of natural causes and corresponding
nonatherosclerotic arteries from 4 otherwise healthy trauma victims were examined. Assays for C pneumoniae DNA
were carried out by nested polymerase chain reaction (nPCR) specific for the C pneumoniae ompA gene. The presence
of the bacterium was assessed by transmission electron microscopy.
Results?Five of the 15 atherosclerotic arterial samples and none of the control tissues were positive for C pneumoniae
by nPCR. Particles similar in morphology and size to C pneumoniae elementary bodies were detected by transmission
electron microscopy in 4 of the 5 nPCR-positive atherosclerotic samples.
Conclusions?The demonstration of C pneumoniae in atherosclerotic middle cerebral arteries is consistent with the hypothesis that this bacterium is involved in acute and chronic cerebrovascular diseases.
Típus:
Article
PeerReviewed
Formátum:
application/pdf
Azonosító:
Virók, Dezső and Kis, Zoltán and Karai, László and Intzédy, László and Burián, Katalin and Szabó, Árpád and Iványi, Béla and Gönczöl, Éva (2001) Chlamydia pneumoniae in atherosclerotic middle cerebral artery. Stroke, 32. pp. 1973-1976. ISSN 0039-2499 (print), 1524-4628 (online)
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