A biexponential DWI study in rat brain intracellular oedema
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Tartalom: http://real.mtak.hu/2772/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
A biexponential DWI study in rat brain intracellular oedema
Létrehozó:
Steier, Roy
Aradi, Mihály
Pál, József
Perlaki, Gábor
Orsi, Gergely
Bogner, Péter
Gallyas, Ferenc
Bukovics, Péter
Janszky, József
Dóczi, Tamás
Schwarcz, Attila
Dátum:
2011
Téma:
R1 Medicine (General) / orvostudomány általában
Tartalmi leírás:
Purpose: To examinethechangesinMRparametersderivedfromdiffusionweightedimaging(DWI)
biexponential analysisinaninvivointracellularbrainoedemamodel,andtoapplyelectronmicroscopy
(EM) toshedmorelightonthemorphologicalbackgroundofMR-relatedobservations.
Materials andmethods: Intracellular oedemawasinducedintenmaleWistarrats(380?450g)bywayof
water load,usinga20%bodyweightintraperitonealinjectionof140mmol/Ldextrosesolution.A3TMRI
instrument wasusedtoperformserialDWI,andMRspecroscopy(watersignal)measurements.Following
the MRexaminationthebrainsoftheanimalswereanalyzedforEM.
Results: Following thewaterloadinduction,apparentdiffusioncoefficient(ADC)valuesstarteddeclining
from 724±43?m2/s to682±26?m2/s (p < 0.0001).
ADC-fast valuesdroppedfrom948±122 to840±66?m2/s (p < 0.001).ADC-slowshowedadecrease
from 226±66 to191±74?m2/s (p < 0.05).
There wasashiftfromtheslowtothefastcomponentat110mintimepoint.Thepercentageofthefast
component demonstratedmoderate,yetsignificantincreasefrom76.56±7.79% to81.2±7.47% (p < 0.05).
The watersignalwasincreasingby4.98±3.52% comparedtothebaseline(p < 0.01).
The resultsoftheE.M.revealedthatwaterwasdetectedintracellularly,withinastrocyticpreivascular
end-feet andcellbodies.
Conclusion: The unexpectedvolumefractionchanges(i.e.increaseinfastcomponent)detectedinhypo-
tonic oedemaappeartobesubstantiallydifferentfromthoseobservedinstroke.ItmaysuggestthatADC
decrease instroke,incontrasttogeneralpresumptions,cannotbeexplainedonlybywatershiftfrom
extra tointracellularspace(i.e.intracellularoedema).
Típus:
Article
PeerReviewed
Formátum:
application/pdf
Azonosító:
Steier, Roy and Aradi, Mihály and Pál, József and Perlaki, Gábor and Orsi, Gergely and Bogner, Péter and Gallyas, Ferenc and Bukovics, Péter and Janszky, József and Dóczi, Tamás and Schwarcz, Attila (2011) A biexponential DWI study in rat brain intracellular oedema. European Journal of Radiology .
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