Traumatic axonal injury in the spinal cord evoked by traumatic brain injury
  • Metaadatok
Tartalom: http://online.liebertpub.com/doi/abs/10.1089/neu.2007.0331
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Traumatic axonal injury in the spinal cord evoked by traumatic brain injury
Létrehozó:
Czeiter, Endre
Pál, József
Kövesdi, Erzsébet
Bukovics, Péter
Lückl, János
Dóczi, Tamás
Büki, András
Kiadó:
Mary Ann Liebert Inc. Publishers
Dátum:
2008-03
Téma:
RB Pathology / patológia, kórtan
Tartalmi leírás:
Although it is well known that traumatic brain injury (TBI) evokes traumatic axonal injury (TAI)
within the brain, TBI-induced axonal damage in the spinal cord (SC) has been less extensively investigated.
Detection of such axonal injury in the spinal cord would further the complexity of TBI
while also challenging some functional neurobehavioral endpoints frequently used to assess recovery
in various models of TBI. To assess TAI in the spinal cord associated with TBI, we analyzed
the craniocervical junction (CCJ), cervico-thoracic (CT), and thoraco-lumber (ThL) spinal cord in
a rodent model of impact acceleration of TBI of varying severities. Rats were transcardially fixed
with aldehydes at 2, 6, and 24 h post-injury (n ? 36); each group included on sham-injured rodent.
Semi-serial vibratome sections were reacted with antibodies targeting TAI via alteration in cytoskeletal
integrity or impaired axonal transport. Consistent with previous observations in this
model, the CCJ contained numerous injured axons. Immunoreactive, damaged axonal profiles were
also detected as caudal, as the ThL spinal cord displayed morphological characteristics entirely consistent
with those described in the brainstem and the CCJ. Quantitative analyses demonstrated that
the occurrence and extent of TAI is positively associated with the impact/energy of injury and negatively
with the distance from the brainstem. These observations show that TBI can evoke TAI in
regions remote from the injury site, including the spinal cord itself. This finding is relevant to shaken
baby syndrome as well as during the analysis of data in functional recovery in various models of
TBI.
Típus:
Article
PeerReviewed
Formátum:
application/pdf
Azonosító:
Czeiter, Endre and Pál, József and Kövesdi, Erzsébet and Bukovics, Péter and Lückl, János and Dóczi, Tamás and Büki, András (2008) Traumatic axonal injury in the spinal cord evoked by traumatic brain injury. JOURNAL OF NEUROTRAUMA, 25 (3). pp. 205-213. ISSN 0897-7151
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